Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes
نویسندگان
چکیده
منابع مشابه
Kupffer cells mediate leptin-induced liver fibrosis.
BACKGROUND & AIMS Leptin has profibrogenic effects in liver, although the mechanisms of this process are unclear. We sought to elucidate the direct and indirect effects of leptin on hepatic stellate cells (HSCs). METHODS HSCs from Sprague-Dawley rats were exposed to leptin and expression of collagen-I, tissue inhibitor of matrix metalloproteinases-1 (TIMP1), transforming growth factor beta1 (...
متن کاملBrowicz or Kupffer cells?
The paper is concerned to problem of discovery of macrofage cells present in the liver sinusoid, which are recognized in the world medical literature as Kuppffer cells. On the other hand in Poland the name of professor Tadeusz Browicz is firmly connected with the cells resulting in eponymous Browicz cells. The authors are trying to determine who has priority in this respect; Karl Kupffer, a pro...
متن کاملAntimicrobial properties of Kupffer cells.
To characterize the antimicrobial activities of Kupffer cells, I harvested macrophages from livers with a technique involving perfusion with collagenase and DNase. Ninety-nine percent of glass-adherent cells had typical macrophage morphology, 99% were esterase positive, and 60% phagocytosed opsonized zymosan when challenged with four particles per macrophage. Toxoplasma gondii multiplied within...
متن کاملDepletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
OBJECTIVE Increased activity of the innate immune system has been implicated in the pathogenesis of the dyslipidemia and insulin resistance associated with obesity and type 2 diabetes. In this study, we addressed the potential role of Kupffer cells (liver-specific macrophages, KCs) in these metabolic abnormalities. RESEARCH DESIGN AND METHODS Rats were depleted of KCs by administration of gad...
متن کاملMononuclear Phagocytes (kupffer Cells) and Endothelial Cells
The fine structural characteristics and phagocytic properties of peroxidase-positive and peroxidase-negative cells in rat hepatic sinusoids were investigated. Cells with a positive peroxidase reaction in the endoplasmic reticulum and the nuclear envelope make up approximately 40% of cells in rat hepatic sinusoids and have abundant cytoplasm containing numerous granules and vacuoles, and occasio...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2019
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2018.07.004